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J Am Acad Dermatol. 2015 Apr;72(4):599-605. doi: 10.1016/j.jaad.2015.01.004. Epub 2015 Feb 1.

Patients with psoriasis are insulin resistant.

Author information

1
Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. Electronic address: mette.gyldenloeve@regionh.dk.
2
Center for Diabetes Research, Department of Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
3
Novo Nordisk Foundation (NNF) Center for Basic Metabolic Research, Department of Biomedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
4
Center for Diabetes Research, Department of Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Novo Nordisk Foundation (NNF) Center for Basic Metabolic Research, Department of Biomedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
5
Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Abstract

BACKGROUND:

Patients with psoriasis have increased risk of type 2 diabetes. The pathophysiology is largely unknown, but it is hypothesized that systemic inflammation causes insulin resistance. Insulin sensitivity has only been sparsely investigated in patients with psoriasis, and previous studies have used suboptimal methodology. The hyperinsulinemic euglycemic clamp remains the gold standard for quantifying whole-body insulin sensitivity.

OBJECTIVE:

We sought to investigate if normal glucose-tolerant patients with psoriasis exhibit impaired insulin sensitivity.

METHODS:

Three-hour hyperinsulinemic euglycemic clamps were performed in 16 patients with moderate to severe, untreated psoriasis and 16 matched control subjects.

RESULTS:

The 2 groups were similar with regard to age, gender, body mass index, body composition, physical activity, fasting plasma glucose, and glycosylated hemoglobin. Mean ± SEM psoriasis duration was 23 ± 3 years and Psoriasis Area and Severity Index score was 12.7 ± 1.4. Patients with psoriasis exhibited reduced insulin sensitivity compared with control subjects (median M-value 4.5 [range 1.6-14.0] vs 7.4 [range 2.1-10.8] mg/kg/min, P = .046). There were no differences between groups in plasma glucose, insulin, C-peptide, and glucagon during the clamp.

LIMITATIONS:

The classic hyperinsulinemic euglycemic clamp technique does not allow assessment of endogenous glucose production.

CONCLUSION:

Patients with psoriasis were more insulin resistant compared with healthy control subjects. This supports that psoriasis may be a prediabetic condition.

KEYWORDS:

M-value; hyperinsulinemic euglycemic clamp; insulin resistance/sensitivity; psoriasis; type 2 diabetes

PMID:
25653028
DOI:
10.1016/j.jaad.2015.01.004
[Indexed for MEDLINE]

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