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BMC Complement Altern Med. 2015 Feb 5;15:3. doi: 10.1186/s12906-015-0517-7.

Effect of Tai Chi on mononuclear cell functions in patients with non-small cell lung cancer.

Author information

1
Department of Martial Arts, Shanghai University of Sport, Shanghai, 200438, China. liujing_j3@163.com.
2
Department of Psychology, School of Kinesiology, University of Michigan, Ann Arbor, MI, 48109, USA. liujing_j3@163.com.
3
Department of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. chengpjk@online.sh.cn.
4
Department of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. wangru0612@163.com.
5
Department of Sports Leisure, Shanghai University of Sport, Shanghai, 200438, China. yuanyonghong@hotmail.com.
6
Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. xwang@hotmail.com.
7
Department of Biochemistry & Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield, 5312 Scott, Detroit, Michigan, 48201, USA. cl@med.wayne.edu.

Abstract

BACKGROUND:

Tai Chi is the Chinese traditional medicine exercise for mind-body health. The objective of this study is to investigate the effect of Tai Chi Chuan (TCC) exercise on the proliferative and cytolytic/tumoricidal activities of peripheral blood mononuclear cells (PBMCs) in postsurgical non-small cell lung cancer (NSCLC) patients.

METHODS:

Patients (n = 27) were randomly divided into the control group (n = 13) and the TCC group (n = 14). TCC group participated in Tai Chi 24-type exercise for 16 weeks, 60-min every time, and three times a week. Peripheral blood was collected and PBMCs isolated before and after the 16-week TCC, PBMC proliferation and co-culture of PBMCs with the NSCLC cell line A549 were performed for proliferation and cell cytolysis assays. Analysis of NKT cells, NK cells, and CD123+ and CD11c + dendritic cells were also performed.

RESULTS:

(1) After 16-week of TCC, cell proliferation increased significantly as compared with the control. (2) PBMCs from the TCC group also demonstrated enhanced cytolytic/oncolytic activity against A549 cells. (3) Significant differences were also found in NK cell percentage at t = 16 weeks, post-pre changes of NKT and DC11c between groups.

CONCLUSION:

Regular Tai Chi exercise has the promise of enhancing PBMC proliferative and cytolytic activities in NSCLC patients. Our results affirm the value of a future trial with a larger scale and longer duration for cancer survivors.

TRIAL REGISTRATION:

ChiCTR-TRC-11001404 .

PMID:
25653009
PMCID:
PMC4321705
DOI:
10.1186/s12906-015-0517-7
[Indexed for MEDLINE]
Free PMC Article

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