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Nature. 2015 Feb 19;518(7539):399-403. doi: 10.1038/nature14182. Epub 2015 Feb 4.

Functional organization of excitatory synaptic strength in primary visual cortex.

Author information

1
Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK.
2
Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH - 4056 Basel, Switzerland.
3
Lui Che Woo Institute of Innovative Medicine and Chow Yuk Ho Technology Center for Innovative Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
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Contributed equally

Abstract

The strength of synaptic connections fundamentally determines how neurons influence each other's firing. Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones. Although this highly skewed distribution of connection strengths is observed in diverse cortical areas, its functional significance remains unknown: it is not clear how connection strength relates to neuronal response properties, nor how strong and weak inputs contribute to information processing in local microcircuits. Here we reveal that the strength of connections between layer 2/3 (L2/3) pyramidal neurons in mouse primary visual cortex (V1) obeys a simple rule--the few strong connections occur between neurons with most correlated responses, while only weak connections link neurons with uncorrelated responses. Moreover, we show that strong and reciprocal connections occur between cells with similar spatial receptive field structure. Although weak connections far outnumber strong connections, each neuron receives the majority of its local excitation from a small number of strong inputs provided by the few neurons with similar responses to visual features. By dominating recurrent excitation, these infrequent yet powerful inputs disproportionately contribute to feature preference and selectivity. Therefore, our results show that the apparently complex organization of excitatory connection strength reflects the similarity of neuronal responses, and suggest that rare, strong connections mediate stimulus-specific response amplification in cortical microcircuits.

PMID:
25652823
PMCID:
PMC4843963
DOI:
10.1038/nature14182
[Indexed for MEDLINE]
Free PMC Article

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