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Microb Ecol Health Dis. 2015 Feb 2;26:26191. doi: 10.3402/mehd.v26.26191. eCollection 2015.

Dysbiosis of the gut microbiota in disease.

Author information

1
Institute of Food Research, Norwich, UK.
2
Norwich Medical School, University of East Anglia, Norwich, UK.
3
Translational Research in GastroIntestinal Disorders, KU Leuven, Leuven, Belgium.
4
Molecular Gastroenterology Research Group, Department of Oncology, University of Sheffield, Sheffield, UK.
5
Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, UK; b.m.corfe@shef.ac.uk.
6
Human Nutrition Unit, Department of Oncology, University of Sheffield, Sheffield, UK.

Abstract

There is growing evidence that dysbiosis of the gut microbiota is associated with the pathogenesis of both intestinal and extra-intestinal disorders. Intestinal disorders include inflammatory bowel disease, irritable bowel syndrome (IBS), and coeliac disease, while extra-intestinal disorders include allergy, asthma, metabolic syndrome, cardiovascular disease, and obesity.

KEYWORDS:

Microbiome; colonic metabolome; gut health; gut–brain–axis; inflammation; short-chain fatty acids

PMID:
25651997
PMCID:
PMC4315779

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