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Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4018-22. doi: 10.1002/anie.201409639. Epub 2015 Feb 4.

Clotting activity of polyphosphate-functionalized silica nanoparticles.

Author information

1
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106 (USA). dkudela@chem.ucsb.edu.

Abstract

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

KEYWORDS:

hemorrhage; nanoparticles; polyphosphates; silicates; trauma

PMID:
25651530
PMCID:
PMC4782980
DOI:
10.1002/anie.201409639
[Indexed for MEDLINE]
Free PMC Article

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