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Cell Metab. 2015 Feb 3;21(2):163-73. doi: 10.1016/j.cmet.2014.12.015.

Semaphorin signaling in cardiovascular development.

Author information

1
Department of Cell and Developmental Biology, Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 USA. Electronic address: epsteinj@upenn.edu.
2
Department of Cell and Developmental Biology, Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 USA.
3
Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, and the National Heart Research Institute Singapore, National Heart Center Singapore, Singapore. Electronic address: manvendra.singh@duke-nus.edu.sg.

Abstract

Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or repulsive signals by forming complexes with plexin and neuropilin receptors. Subsequent research has identified functions for semaphorin signaling in many organs and tissues outside of the nervous system. Vital roles for semaphorin signaling in vascular patterning and cardiac morphogenesis have been demonstrated, and impaired semaphorin signaling has been associated with various human cardiovascular disorders, including persistent truncus arteriosus, sinus bradycardia and anomalous pulmonary venous connections. Here, we review the functions of semaphorins and their receptors in cardiovascular development and disease and highlight important recent discoveries in the field.

PMID:
25651171
DOI:
10.1016/j.cmet.2014.12.015
[Indexed for MEDLINE]
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