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Cell Metab. 2015 Feb 3;21(2):159-162. doi: 10.1016/j.cmet.2015.01.003.

Metformin action: concentrations matter.

Author information

1
Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
2
Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: fwondis1@jhmi.edu.

Abstract

Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

PMID:
25651170
DOI:
10.1016/j.cmet.2015.01.003
[Indexed for MEDLINE]
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