Format

Send to

Choose Destination
See comment in PubMed Commons below
Scand J Med Sci Sports. 2015 Apr;25(2):e149-54. doi: 10.1111/sms.12421. Epub 2015 Feb 3.

Circulating microRNAs in response to exercise.

Author information

1
Regeneration and Ageing Lab and Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China; Shanghai Key Laboratory of Bio-Energy Crops, School of Life Science, Shanghai, China.

Abstract

MicroRNAs (miRNAs, miRs) are a novel class of endogenous noncoding RNAs, which post-transcriptionally regulate gene expression via mRNA degradation or translational inhibition. miRNAs have become increasingly recognized as central players in the process of gene regulation and are responsible for a variety of essential biological processes including proliferation, differentiation and metabolism. miRNAs can be released into the circulation where they remain stable. Exercise is one of the most positive and effective means of achieving enhanced physique. This review highlights and summarizes recent progress in the field of circulating miRNAs in response to acute and chronic exercise and discusses future directions in studying circulating miRNAs in exercise-induced adaptation. A better understanding of how circulating miRNAs participate in the physiological response to exercise would eventually help develop circulating miRNAs as therapeutic targets for improving exercise capacity in patients with heart failure and other diseases.

KEYWORDS:

Circulating microRNA; adaptation; exercise

PMID:
25648616
DOI:
10.1111/sms.12421
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center