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J Biomech. 2015 Feb 26;48(4):708-11. doi: 10.1016/j.jbiomech.2015.01.014. Epub 2015 Jan 21.

Microstructural and mechanical characterization of scarred vocal folds.

Author information

1
Biomechanics Laboratory, Department of Mechanical Engineering, McGill University, 817 rue Sherbrooke Ouest, Montreal, QC, Canada H3A 0C3.
2
Biomechanics Laboratory, Department of Mechanical Engineering, McGill University, 817 rue Sherbrooke Ouest, Montreal, QC, Canada H3A 0C3. Electronic address: amir.miriramsheh@mail.mcgill.ca.
3
Physics and Chemistry Departments, McGill University, 3600 rue University, Montreal, QC, Canada H3A 2T8.
4
School of Communication Sciences and Disorders, McGill University, 2001 McGill College, Montreal, QC, Canada H3A 1G1.
5
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792, United States.

Abstract

The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

KEYWORDS:

Atomic force microscopy; Scarring; Second harmonic generation; Vocal fold

PMID:
25648495
PMCID:
PMC4337956
DOI:
10.1016/j.jbiomech.2015.01.014
[Indexed for MEDLINE]
Free PMC Article

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