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Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.

Developmental biology. Regional identity of gut stem cells--one gene to rule them all.

Author information

1
Division of Developmental Biology and Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

Abstract

The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.

PMID:
25645971
DOI:
10.1038/nrgastro.2015.22
[Indexed for MEDLINE]

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