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Nat Rev Genet. 2015 Mar;16(3):146-58. doi: 10.1038/nrg3885. Epub 2015 Feb 3.

Quantitative and logic modelling of molecular and gene networks.

Author information

1
Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

Abstract

Behaviours of complex biomolecular systems are often irreducible to the elementary properties of their individual components. Explanatory and predictive mathematical models are therefore useful for fully understanding and precisely engineering cellular functions. The development and analyses of these models require their adaptation to the problems that need to be solved and the type and amount of available genetic or molecular data. Quantitative and logic modelling are among the main methods currently used to model molecular and gene networks. Each approach comes with inherent advantages and weaknesses. Recent developments show that hybrid approaches will become essential for further progress in synthetic biology and in the development of virtual organisms.

PMID:
25645874
PMCID:
PMC4604653
DOI:
10.1038/nrg3885
[Indexed for MEDLINE]
Free PMC Article

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