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Magn Reson Imaging. 2015 May;33(4):413-9. doi: 10.1016/j.mri.2014.11.005. Epub 2015 Jan 30.

Ultra-high-resolution MR imaging of esophageal carcinoma at ultra-high field strength (7.0T) ex vivo: correlation with histopathologic findings.

Author information

1
Department of Diagnostic Radiology and Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: yamada.crad@tmd.ac.jp.
2
Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
3
Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Central Institute for Experimental Animals, Kanagawa, Japan.
4
Department of Esophagogastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
5
Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
6
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Abstract

PURPOSE:

To determine the usefulness of ultra-high-resolution magnetic resonance (MR) imaging at an ultra-high field strength (7.0T), using a voxel volume of 9.5-14nL, as means of evaluating the depth of mural invasion by esophageal carcinomas.

MATERIALS AND METHODS:

Twenty esophageal specimens containing 20 carcinomas were studied using a 7.0-T MR imaging system with a four-channel surface coil. Ultra-high-resolution MR images were obtained with a field of view of 50-60mm×25-30mm, a matrix of 512×256, and a section thickness of 1.0mm, resulting in a voxel volume of 0.0095-0.014mm(3) (9.5-14nL). Differences between tumor tissue and the esophageal wall layers and between tumor tissue and fibrosis were evaluated using visual signal intensity scoring measurements. MR images were then compared with histopathologic findings as the reference standard.

RESULTS:

Ultra-high-resolution T2-weighted MR images at 7.0T clearly depicted the normal esophageal wall in all 20 specimens (100%) as consisting of eight layers, which clearly corresponded to the tissue layers of the esophageal wall. Ultra-high-resolution T2-weighted MR images made it possible to differentiate between the tumor tissue and fibrosis clearly (P<0.01). In all 20 esophageal carcinomas (100%), ultra-high-resolution T2-weighted MR images made it possible to determine the depth of tumor invasion in the esophageal wall as observed in the histopathologic sections. Regional lymph node involvement was also clearly depicted in four specimens.

CONCLUSION:

Ultra-high-resolution 7.0-T MR imaging, using a voxel volume of 9.5-14nL, provides clear delineation of the esophageal wall layers, clear differentiation of tumor tissue from fibrosis, and excellent diagnostic accuracy for evaluating mural invasion by esophageal carcinomas.

KEYWORDS:

Esophageal carcinoma; Esophagus; MR imaging; Ultra-high field strength; Ultra-high spatial resolution

PMID:
25645396
DOI:
10.1016/j.mri.2014.11.005
[Indexed for MEDLINE]

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