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J Nutr. 2015 Feb;145(2):299-305. doi: 10.3945/jn.114.203505. Epub 2014 Dec 10.

Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease.

Author information

1
Departments of Heart Disease Departments of Clinical Science nathalie.genevieve.puaschitz@helse-bergen.no.
2
Departments of Clinical Science.
3
Departments of Heart Disease Research and Development, and Departments of Clinical Science.
4
Clinical Medicine, and.
5
The National Institute of Nutrition and Seafood Research, Bergen, Norway; and.
6
Departments of Heart Disease Departments of Clinical Science.
7
Research and Development, and.
8
Rheumatology, Haukeland University Hospital, Bergen, Norway Global Public Health and Primary Care, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway The National Institute of Nutrition and Seafood Research, Bergen, Norway; and.
9
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
10
Global Public Health and Primary Care, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.

Abstract

BACKGROUND:

Data from recent meta-analyses question an association between dietary intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively studied.

OBJECTIVE:

We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).

METHODS:

This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.

RESULTS:

This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.

CONCLUSIONS:

There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD.

KEYWORDS:

FFQ; coronary events; dietary SFA; established coronary artery disease; mortality

PMID:
25644351
DOI:
10.3945/jn.114.203505
[Indexed for MEDLINE]

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