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Bone Marrow Transplant. 2015 Apr;50(4):476-82. doi: 10.1038/bmt.2014.312. Epub 2015 Feb 2.

Hematopoietic SCT in Europe 2013: recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants.

Author information

1
EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
2
Universitätsklinikum Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.
3
Ospedale San Raffaele, Milan, Italy.
4
Paediatric Haematology Oncology, Policlinico G.B. Rossi, Verona, Italy.
5
Medizinische Klinik V, University of Heidelberg, Heidelberg, Germany.
6
Hospital Duran i Reynals, Barcelona, Spain.
7
Institute G. Gaslini, Genova, Italy.
8
Department of Hematology, University Medical Center, Leiden, The Netherlands.
9
Service de Médecine Interne, Hopital St Louis, Paris, France.
10
Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK.
11
University Hospital Eppendorf, Hamburg, Germany.
12
Hematology and BMT Unit, Cremona, Italy.
13
Chaim Sheba Medical Center, Tel-Hashomer, Israel.
14
Hospital Saint Antoine, Paris, France.

Abstract

A record number of 39,209 HSCT in 34,809 patients (14,950 allogeneic (43%) and 19,859 autologous (57%)) were reported by 658 centers in 48 countries to the 2013 survey. Trends include: more growth in allogeneic than in autologous HSCT, increasing use of sibling and unrelated donors and a pronounced increase in haploidentical family donors when compared with cord blood donors for those patients without a matched related or unrelated donor. Main indications were leukemias, 11,190 (32%; 96% allogeneic); lymphoid neoplasias, 19,958 (57%; 11% allogeneic); solid tumors, 1543 (4%; 4% allogeneic); and nonmalignant disorders, 1975 (6%; 91% allogeneic). In patients without a matched sibling or unrelated donor, alternative donors are used. Since 2010 there has been a marked increase of 96% in the number of transplants performed from haploidentical relatives (802 in 2010 to 1571 in 2013), whereas the number of unrelated cord blood transplants has slightly decreased (789 in 2010 to 666 in 2013). The use of donor type varies greatly throughout Europe.

PMID:
25642761
PMCID:
PMC4387247
DOI:
10.1038/bmt.2014.312
[Indexed for MEDLINE]
Free PMC Article

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