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Clin Sarcoma Res. 2015 Jan 24;5(1):4. doi: 10.1186/s13569-014-0020-9. eCollection 2015.

Ganglioside GD2 expression is maintained upon recurrence in patients with osteosarcoma.

Author information

1
Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Ave, Rosenthal Pavilion, Room 300, Bronx, NY 10467 USA.
2
Department of Orthopaedic Surgery, Montefiore Medical Center and the Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY USA.
3
Department of Pathology, Seattle Children's Hospital and University of Washington, Seattle, WA USA.
4
Division of Pediatric Hematology/Oncology, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, and University of Washington, Seattle, WA USA.
5
Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Ave, Rosenthal Pavilion, Room 300, Bronx, NY 10467 USA ; Department of Pediatrics and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY USA.

Abstract

BACKGROUND:

Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Ganglioside GD2 has been previously found on the cell surface in various tumor types, including osteosarcomas.

FINDINGS:

In this study, forty-nine additional osteosarcoma samples from 14 individual patients were assessed for GD2 expression via immunohistochemistry, of which 47 samples were found to express GD2. In matched samples from patients, GD2 expression seen at initial biopsy was found to persist in 100% of tissues taken at recurrence.

CONCLUSIONS:

GD2 expression was found to persist upon recurrence. These results suggest a phase 2 trial in children with recurrent osteosarcoma should provide an appropriate read out on the efficacy of anti-GD2 antibody.

KEYWORDS:

Antibody; Ganglioside GD2; Immunotherapy; Osteosarcoma

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