Format

Send to

Choose Destination
Front Cell Neurosci. 2015 Jan 14;8:461. doi: 10.3389/fncel.2014.00461. eCollection 2014.

The role of microglia and myeloid immune cells in acute cerebral ischemia.

Author information

1
Feil Family Brain and Mind Research Institute, Weill Cornell Medical College New York, NY, USA.

Abstract

The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke.

KEYWORDS:

cerebral ischemia; microglia; monocytes; myeloid cells; neutrophils; tissue macrophages

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center