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Small. 2015 Jun 10;11(22):2607-13. doi: 10.1002/smll.201402650. Epub 2015 Jan 29.

Microfluidic Single-Cell Analysis with Affinity Beads.

Author information

1
Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), 1015, Lausanne, Switzerland.

Abstract

A micrometer-sized affinity bead (red) is (i) taken up into a cell by phagocytosis, (ii) photochemically released from phagosomes, (iii) optically trapped by the cell, and (iv) isolated by cell lysis for subsequent analysis of captured intracellular analyte (green).

KEYWORDS:

affinity beads; microfluidics; optical tweezers; photochemical internalization; single-cell analysis

PMID:
25641862
DOI:
10.1002/smll.201402650
[Indexed for MEDLINE]

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