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Proteomics Clin Appl. 2015 Jun;9(5-6):453-68. doi: 10.1002/prca.201400113. Epub 2015 Apr 7.

Capillary zone electrophoresis on-line coupled to mass spectrometry: A perspective application for clinical proteomics.

Author information

1
Mosaiques Diagnostics GmbH, Hanover, Germany.
2
Biotechnology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
3
School of Biomedical and Healthcare Sciences, Plymouth University, Plymouth, UK.
4
Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.

Abstract

Clinical proteomics, a rapidly growing field, intends to use specific diagnostic proteomic/peptidomic markers for initial diagnosis or prognosis of the progression of various diseases. Analyses of disease-associated markers in defined biological samples can provide valuable molecular diagnostic information for these diseases. This approach relies on sensitive and highly standardized modern analytical techniques. In the recent years, one of these technologies, CZE online coupled to MS (CZE-MS), has been increasingly used for the detection of peptide biomarkers (<20 kDa) in body fluids such as urine. This review presents the most relevant urinary proteomic studies addressing the application of CZE-MS in clinically relevant biomarker research between the years 2006 and 2014.

KEYWORDS:

Biomarker; Capillary electrophoresis-mass spectrometry; Clinical; Proteomics

PMID:
25641766
DOI:
10.1002/prca.201400113
[Indexed for MEDLINE]

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