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Cell Metab. 2015 Mar 3;21(3):357-68. doi: 10.1016/j.cmet.2014.12.020. Epub 2015 Jan 29.

Rare and common genetic events in type 2 diabetes: what should biologists know?

Author information

1
CNRS-UMR8199, Lille Pasteur Institute, Lille 59000, France; Lille University, Lille 59000, France; European Genomic Institute for Diabetes (EGID), Lille 59000, France.
2
CNRS-UMR8199, Lille Pasteur Institute, Lille 59000, France; Lille University, Lille 59000, France; European Genomic Institute for Diabetes (EGID), Lille 59000, France; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. Electronic address: philippe.froguel@good.ibl.fr.

Abstract

Type 2 diabetes (T2D) had long been referred to as the "geneticist's nightmare." Genome-wide association studies have fully confirmed the polygenic nature of T2D, demonstrating the role of many genes in T2D risk. The increasingly busier picture of T2D genetics is quite difficult to understand for the diabetes research community, which can create misunderstandings with geneticists, and can eventually limit both basic research and translational outcomes of these genetic discoveries. The present review wishes to lift the fog around genetics of T2D with the hope that it will foster integrated diabetes modeling approaches from genetic defects to personalized medicine.

PMID:
25640731
DOI:
10.1016/j.cmet.2014.12.020
[Indexed for MEDLINE]
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