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Br J Nutr. 2015 Feb 28;113(4):665-71. doi: 10.1017/S000711451400395X. Epub 2015 Feb 2.

Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study.

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Cancer Prevention and Control Program, University of South Carolina,915 Greene Street, Suite 241,Columbia,SC29208,USA.
Department of Cardiovascular Diseases,Ghent University,Ghent,Belgium.
Asklepios Core-Lab, Department of Laboratory Medicine, AZ St-Jan,Brugge,Belgium.
Department of Metabolism and Nutrition,Institute of Food Science and Technology and Nutrition,Madrid,Spain.
Department of Public Health,Ghent University,Ghent,Belgium.


Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of a FFQ-derived dietary inflammatory index (DII) to predict inflammation. Data from a Belgian cross-sectional study of 2524 generally healthy subjects (age 35-55 years) were used. The DII is a population-based, literature-derived dietary index that was developed to predict inflammation and inflammation-related chronic diseases. The DII was calculated from FFQ-derived dietary information and tested against inflammatory markers, namely C-reactive protein (CRP), IL-6, homocysteine and fibrinogen. Analyses were performed using multivariable logistic regression, adjusting for energy, age, sex, BMI, smoking status, education level, use of non-steroidal anti-inflammatory drugs, blood pressure, use of oral contraceptives, anti-hypertensive therapy, lipid-lowering drugs and physical activity. Multivariable analyses showed significant positive associations between the DII and the inflammatory markers IL-6 (>1·6 pg/ml) (OR 1·19, 95 % CI 1·04, 1·36) and homocysteine (>15 μmol/l) (OR 1·56, 95 % CI 1·25, 1·94). No significant associations were observed between the DII and the inflammatory markers CRP and fibrinogen. These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation.


Chronic disease risk

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