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J Bone Miner Res. 2015 Feb;30(2):199-211. doi: 10.1002/jbmr.2446.

Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.

Author information

1
Division of Endocrinology, Oregon Health and Science University, Portland, OR, USA; Bone and Mineral Unit, Oregon Health and Science University, Portland, OR, USA.

Abstract

Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults-a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.

KEYWORDS:

BONE MINERAL DENSITY (BMD); BONE REMODELING; CIRCADIAN RHYTHM; FRACTURE; NOCTURNAL HYPOXIA; OBSTRUCTIVE SLEEP APNEA (OSA); REVIEW; SLEEP; SLEEP LOSS

PMID:
25639209
PMCID:
PMC4572893
DOI:
10.1002/jbmr.2446
[Indexed for MEDLINE]
Free PMC Article

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