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Nitric Oxide. 2015 Feb 15;45:20-6. doi: 10.1016/j.niox.2015.01.006. Epub 2015 Jan 28.

Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals.

Author information

1
Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France; BioSciences Master, Department of Biology, Ecole Normale Supérieure de Lyon, University Lyon 1, Lyon, France.
2
Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France.
3
Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France. Electronic address: romain.debret@ibcp.fr.

Abstract

Blood vessels are continuously exposed to various stresses such as mechanical strains and neurosignals. Besides its role as a barrier between blood and other tissues, the endothelium is a highly important cell layer for the regulation of vascular tone. Indeed, depending on the signal perceived by endothelial cells, it can drive a vasoconstrictor or vasodilator signal. This review presents mechano-receptors and neuro-receptors (restricted to neuropeptides) leading to vessel relaxation via the production of nitric oxide. Finally, some pieces of evidence of a potential cross-talk between these two kinds of stimuli are discussed.

KEYWORDS:

Endothelial nitric oxide synthase; Endothelium; Mechanosensing; Neurosensing; Vasodilation

PMID:
25638487
DOI:
10.1016/j.niox.2015.01.006
[Indexed for MEDLINE]

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