Format

Send to

Choose Destination
Neurobiol Learn Mem. 2015 Jul;122:110-21. doi: 10.1016/j.nlm.2015.01.008. Epub 2015 Jan 28.

The role of rapid eye movement sleep for amygdala-related memory processing.

Author information

1
CCNS, University of Edinburgh, Edinburgh, UK. Electronic address: lgenzel@ed.ac.uk.
2
Max Planck Institute of Psychiatry, Munich, Germany.
3
Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
4
Max Planck Institute of Psychiatry, Munich, Germany; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands. Electronic address: martin.dresler@donders.ru.nl.

Abstract

Over the years, rapid eye movement (REM) sleep has been associated with general memory consolidation, specific consolidation of perceptual, procedural, emotional and fear memories, brain maturation and preparation of waking consciousness. More recently, some of these associations (e.g., general and procedural memory consolidation) have been shown to be unlikely, while others (e.g., brain maturation and consciousness) remain inconclusive. In this review, we argue that both behavioral and neurophysiological evidence supports a role of REM sleep for amygdala-related memory processing: the amygdala-hippocampus-medial prefrontal cortex network involved in emotional processing, fear memory and valence consolidation shows strongest activity during REM sleep, in contrast to the hippocampus-medial prefrontal cortex only network which is more active during non-REM sleep. However, more research is needed to fully understand the mechanisms.

KEYWORDS:

Amygdala; Hippocampus; Learning; Memory; REM; Sleep; mPFC

PMID:
25638277
DOI:
10.1016/j.nlm.2015.01.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Edinburgh Research Explorer, University of Edinburgh
Loading ...
Support Center