Format

Send to

Choose Destination
BMC Biol. 2015 Jan 31;13:7. doi: 10.1186/s12915-015-0118-4.

Aging and DNA methylation.

Author information

1
Beckman Research Institute, Duarte 91010, CA, USA. marcjungphd@gmail.com.

Abstract

In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.

PMID:
25637097
PMCID:
PMC4311512
DOI:
10.1186/s12915-015-0118-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center