Format

Send to

Choose Destination
BMJ Open. 2015 Jan 30;5(1):e005624. doi: 10.1136/bmjopen-2014-005624.

Incidence of renal replacement therapy for diabetic nephropathy in the Netherlands: Dutch diabetes estimates (DUDE)-3.

Author information

1
Diabetes Centre, Isala, Zwolle, The Netherlands.
2
Department of Medical Informatics, Academic Medical Center, University of Amsterdam, ERA-EDTA Registry, Amsterdam, The Netherlands.
3
Diabetes Centre, Isala, Zwolle, The Netherlands Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
4
Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands RENINE Registry, Leiden, The Netherlands.
5
Diabetes Centre, Isala, Zwolle, The Netherlands Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands Department of Internal Medicine, Isala, Zwolle, The Netherlands.

Abstract

OBJECTIVES:

Describe the incidence, prevalence and survival of patients needing renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetes mellitus (DM)-related glomerulosclerosis or nephropathy (diabetic nephropathy, DN) in the Netherlands.

DESIGN:

Using the national registry for RRT (RENINE-registry), data of all Dutch individuals initiating RRT for ESRD and having DN as primary diagnosis in the period 2000-2012 were obtained.

SETTING:

Observational study in the Netherlands.

PATIENTS:

Patients with ESRD needing RRT for DN.

OUTCOME MEASUREMENTS:

Age and gender adjusted incidence and prevalence of RRT for DN in the period 2000-2012. In addition, trends in time and patient's survival were examined.

RESULTS:

The prevalence of DM in the general population increased from approximately 466 000 in 2000 to 815 000 in 2011. The number of individuals who started RRT with DN as primary diagnosis was 17.4 per million population (pmp) in 2000 and 19.1 pmp in 2012, with an annual percentage change (APC) of 0.8% (95% CI -0.4 to 2.0). For RRT due to type 1 DN, the incidence decreased from 7.3 to 3.5 pmp (APC -4.8%, 95% CI -6.5 to -3.1) while it increased for type 2 DN from 10.1 to 15.6 pmp (APC 3.1%, 95% CI 1.3 to 4.8). After 2009, the prevalence of RRT for DN remained stable (APC 1.0%, 95% CI -0.4 to 2.5). Compared to the period 2000-2004, patients initiating RRT and dialysis in 2005-2009 had better survival, HRs 0.8 (95% CI 0.7 to 0.8) and 0.8 (95% CI 0.7 to 0.9), respectively, while survival after kidney transplantation remained stable, HR 0.8, 95% CI 0.5 to 1.1).

CONCLUSIONS:

Over the last decade, the incidence of RRT for DN was stable, with a decrease in RRT due to type 1 DN and an increase due to type 2 DN, while survival increased.

KEYWORDS:

DIABETES & ENDOCRINOLOGY; SOCIAL MEDICINE

PMID:
25636789
PMCID:
PMC4316478
DOI:
10.1136/bmjopen-2014-005624
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center