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Transplant Rev (Orlando). 2015 Apr;29(2):68-72. doi: 10.1016/j.trre.2015.01.003. Epub 2015 Jan 14.

Circulating biomarkers of tolerance.

Author information

1
Transplant Laboratory, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
2
Department of Nephrology, Transplant Laboratory, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Electronic address: ondrej.viklicky@medicon.cz.

Abstract

On the basis of reviewed literature here we describe models of tolerance and summarize the evidence of circulating biomarkers suitable for the assessment of immunological risk in organ transplantation. We focused on results of evaluation of specific peripheral immune cell populations and transcripts in peripheral blood of operationally tolerant liver and kidney transplant recipients. Validation of described markers to define potentially tolerant patients before their use in clinical trials is critical.

PMID:
25636718
DOI:
10.1016/j.trre.2015.01.003
[Indexed for MEDLINE]

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