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Curr Opin Neurobiol. 2015 Jun;32:78-86. doi: 10.1016/j.conb.2015.01.007. Epub 2015 Jan 28.

Large-scale imaging in small brains.

Author information

1
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. Electronic address: ahrensm@janelia.hhmi.org.
2
Harvard University, Department of Molecular and Cellular Biology, Cambridge, MA, USA. Electronic address: florian@mcb.harvard.edu.

Abstract

The dense connectivity in the brain means that one neuron's activity can influence many others. To observe this interconnected system comprehensively, an aspiration within neuroscience is to record from as many neurons as possible at the same time. There are two useful routes toward this goal: one is to expand the spatial extent of functional imaging techniques, and the second is to use animals with small brains. Here we review recent progress toward imaging many neurons and complete populations of identified neurons in small vertebrates and invertebrates.

PMID:
25636154
PMCID:
PMC4955592
DOI:
10.1016/j.conb.2015.01.007
[Indexed for MEDLINE]
Free PMC Article

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