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Int J Mol Sci. 2015 Jan 28;16(2):2942-55. doi: 10.3390/ijms16022942.

A time to kill: targeting apoptosis in cancer.

Author information

1
Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. jkoff@emory.edu.
2
Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. sramac2@emory.edu.
3
Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. lbernal@emory.edu.

Abstract

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.

PMID:
25636036
PMCID:
PMC4346874
DOI:
10.3390/ijms16022942
[Indexed for MEDLINE]
Free PMC Article

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