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Kidney Int. 2015 Feb;87(2):268-70. doi: 10.1038/ki.2014.320.

Urea for hyponatremia?

Author information

1
1] Department of Medicine, Rochester General Hospital, Rochester, New York, USA [2] Department of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Abstract

Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia. The 2014 European Clinical Practice Guidelines recommend urea for the treatment of the syndrome of inappropriate antidiuretic hormone, while discouraging use of vasopressin antagonists. Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection.

PMID:
25635717
DOI:
10.1038/ki.2014.320
[Indexed for MEDLINE]

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