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J Infect Dis. 2015 Jun 15;211(12):1925-35. doi: 10.1093/infdis/jiv049. Epub 2015 Jan 29.

A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.

Author information

1
Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.
2
Environmental Health Institute, National Environment Agency, Singapore.
3
Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
4
Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis Institute of Infection and Global Health, University of Liverpool, United Kingdom.

Abstract

BACKGROUND:

Individuals infected with chikungunya virus (CHIKV) normally exhibit a variety of clinical manifestations during the acute phase of infection. However, studies in different patient cohorts have revealed that disease manifestations vary in frequency.

METHODS:

Disease profiles between patients with acute CHIKV-infection and febrile patients without CHIKV were compared and examined to determine whether any clinical presentations were associated with the clinical outcome of CHIKV infection. Circulatory immune mediators profiles were then characterized and compared with data from 14 independent patient cohort studies. The particular immune mediator signature that defines acute CHIKV infection was determined.

RESULTS:

Our findings revealed a specific pattern of clinical presentations of joint-specific arthralgia from this CHIKV cohort. More importantly, we identified an immune mediator signature dominated by proinflammatory cytokines, which include interferon α and γ and interleukin 2, 2R, 6, 7, 12, 15, 17, and 18, across different patient cohorts of CHIKV load associated with arthralgia.

CONCLUSIONS:

To our knowledge, this is the first study that associated levels of CHIKV load with arthralgia as an indicator of acute CHIKV infection. Importantly, our findings also revealed specific immune mediator signatures that can be used to better define CHIKV infection.

KEYWORDS:

acute infection; chemokines; chikungunya virus; cytokines; meta-analysis

PMID:
25635123
PMCID:
PMC4442625
DOI:
10.1093/infdis/jiv049
[Indexed for MEDLINE]
Free PMC Article

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