Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria

Methods Mol Biol. 2015:1265:73-83. doi: 10.1007/978-1-4939-2288-8_6.

Abstract

As mitochondria have an important role as ATP supplier, cellular ROS producer and apoptosis regulator, these organelles are a promising target for pharmacological intervention in the treatment and management of several diseases. Consequently, research on mitochondria-targeted drugs, which exclude other intracellular structures or extracellular processes, is becoming a hot topic. One approach to address the specific targeting is to conjugate bioactive molecules to a lipophilic cation such as the triphenylphosphonium (TPP(+)). In this chapter, the development of a new antioxidant based on the dietary cinnamic acid-caffeic acid-is described as well as the demonstration of its mitochondriotropic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Antioxidants / chemical synthesis
  • Antioxidants / metabolism
  • Caffeic Acids / administration & dosage*
  • Caffeic Acids / chemical synthesis
  • Caffeic Acids / metabolism
  • Cell Fractionation / methods
  • Mitochondria / drug effects*
  • Mitochondria / metabolism*
  • Mitochondria, Liver / drug effects
  • Mitochondria, Liver / metabolism
  • Rats

Substances

  • Antioxidants
  • Caffeic Acids
  • caffeic acid