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Expert Opin Ther Pat. 2015 May;25(5):619-24. doi: 10.1517/13543776.2015.1007954. Epub 2015 Jan 29.

Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344.

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University of Cincinnati, College of Medicine, Department of Molecular Genetics, Biochemistry and Microbiology , Cincinnati, OH, 45267 , USA.


Muscular dystrophies (MD) are commonly characterized by progressive loss of muscle mass and function. It is hypothesized that therapeutic blockade of the TGF-β ligand myostatin, a negative regulator of muscle mass, will stimulate muscle growth and restore muscle function. Although many anti-myostatin targets are currently being pursued in the clinical setting, the efficacies of the tested molecules have shown mixed results. The patent WO2014043344 describes a novel approach for myostatin inhibition using a modified fibronectin type III domain that could potentially be used to treat MD and other muscle-related pathologies.


TGF-β; biological therapies; fibronectin; growth and differentiation factor-8; muscle wasting; muscular dystrophy; myostatin

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