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Horm Res Paediatr. 2015;83(3):198-203. doi: 10.1159/000370046. Epub 2015 Jan 28.

The Association between Vitamin D Levels and Urinary Tract Infection in Children.

Author information

1
Department of Pediatrics, School of Medicine, Adiyaman University, Adiyaman, Turkey.

Abstract

AIM:

We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and urinary tract infection (UTI) among children.

METHODS:

White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, and serum 25(OH)D3 levels were measured in 82 children experiencing a first episode of UTI, with no risk factors for UTI, and 64 healthy control children.

RESULTS:

The mean serum levels of 25(OH)D3 among children with UTI were significantly lower than those of controls (11.7 ± 3.3 vs. 27.6 ± 4.7 ng/ml; p < 0.001). The serum levels of 25(OH)D3 were significantly lower in patients with acute pyelonephritis compared to patients with lower UTI (8.6 ± 2.8 vs. 14.2 ± 3.0 ng/ml; p < 0.001). Within the study group, mean serum levels of 25(OH)D3 among girls were lower than those of boys (10.9 ± 3.4 ng/ml vs. 13.2 ± 4.4 ng/ml; p < 0.001). Multivariate analysis showed that a serum 25(OH)D3 level of <20 ng/ml (odds ratio 3.503, 95% confidence interval 1.621-7.571; p = 0.001) was associated with UTI in children.

CONCLUSIONS:

Our results suggest that vitamin D deficiency may be a risk factor for UTI in children.

PMID:
25632848
DOI:
10.1159/000370046
[Indexed for MEDLINE]

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