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  • PMID: 25632403 was deleted because it is a duplicate of PMID: 26158055
J Med Imaging (Bellingham). 2014 Oct;1(3):033502. doi: 10.1117/1.JMI.1.3.033502. Epub 2014 Nov 3.

Quantitative simultaneous positron emission tomography and magnetic resonance imaging.

Author information

1
Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States.
2
Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States ; Sorbonne Universit├ęs , UPMC Univ Paris 06, Paris 75634, France.
3
Harvard Medical School , Department of Radiology, Boston, Massachusetts 02114, United States ; Massachusetts General Hospital , Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, United States.
4
Massachusetts General Hospital , Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, Massachusetts 02114, United States.

Abstract

Simultaneous positron emission tomography and magnetic resonance imaging (PET-MR) is an innovative and promising imaging modality that is generating substantial interest in the medical imaging community, while offering many challenges and opportunities. In this study, we investigated whether MR surface coils need to be accounted for in PET attenuation correction. Furthermore, we integrated motion correction, attenuation correction, and point spread function modeling into a single PET reconstruction framework. We applied our reconstruction framework to in vivo animal and patient PET-MR studies. We have demonstrated that our approach greatly improved PET image quality.

KEYWORDS:

motion correction; point spread function modeling; positron emission tomography and magnetic resonance imaging; positron emission tomography attenuation correction; surface coils

PMID:
26158055
PMCID:
PMC4306197
DOI:
10.1117/1.JMI.1.3.033502

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