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J Neurosci. 2015 Jan 28;35(4):1513-20. doi: 10.1523/JNEUROSCI.3387-14.2015.

Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe.

Author information

1
Department of Neurosurgery and taylor-abel@uiowa.edu.
2
Department of Neurosurgery and.
3
Newcastle Auditory Group, Medical School, Newcastle University, Newcastle-upon-Tyne NE1 7RU, United Kingdom.
4
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, and.

Abstract

Retrieving the names of friends, loved ones, and famous people is a fundamental human ability. This ability depends on the left anterior temporal lobe (ATL), where lesions can be associated with impaired naming of people regardless of modality (e.g., picture or voice). This finding has led to the idea that the left ATL is a modality-independent convergence region for proper naming. Hypotheses for how proper-name dispositions are organized within the left ATL include both a single modality-independent (heteromodal) convergence region and spatially discrete modality-dependent (unimodal) regions. Here we show direct electrophysiologic evidence that the left ATL is heteromodal for proper-name retrieval. Using intracranial recordings placed directly on the surface of the left ATL in human subjects, we demonstrate nearly identical responses to picture and voice stimuli of famous U.S. politicians during a naming task. Our results demonstrate convergent and robust large-scale neurophysiologic responses to picture and voice naming in the human left ATL. This finding supports the idea of heteromodal (i.e., transmodal) dispositions for proper naming in the left ATL.

KEYWORDS:

electrocorticography; language; naming; temporal pole

PMID:
25632128
PMCID:
PMC4308598
DOI:
10.1523/JNEUROSCI.3387-14.2015
[Indexed for MEDLINE]
Free PMC Article

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