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Angiology. 2015 Oct;66(9):856-61. doi: 10.1177/0003319714568792. Epub 2015 Jan 27.

Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrome.

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Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman.
Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
Department of Biochemistry, College of Medicine & Health Science, Sultan Qaboos University, Muscat, Oman.
Department of Drug Sciences, University of Catania, Catania, Italy.
Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy


The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 ± 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 ± 13.5 to 79.4 ± 12.5 kg, P < .0001), body mass index (from 29.6 [23.7] to 29.3 [21.9] kg/m(2), P = .001), and waist circumference (from 105 ± 11 to 102 ± 10 cm, P = .0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P = .014) and total cholesterol (from 4.8 ± 1.4 to 4.5 ± 1.0 mmol/L, P = .03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.


Curcuma longa; chlorogenic acid; cholesterol; guggul; inulin; metabolic syndrome; natural supplement; oxidative stress; silymarin

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