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Lab Chip. 2015 Mar 21;15(6):1407-11. doi: 10.1039/c4lc01366b.

Integrating nanopore sensors within microfluidic channel arrays using controlled breakdown.

Author information

1
Department of Physics, University of Ottawa, 150 Louis Pasteur, K1N 6N5, Canada.

Abstract

Nanopore arrays are fabricated by controlled dielectric breakdown (CBD) in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced. Both DNA and protein molecules are detected to validate the performance of this sensing platform.

PMID:
25631885
DOI:
10.1039/c4lc01366b
[Indexed for MEDLINE]

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