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Int J Occup Environ Health. 2015 Jul-Sep;21(3):241-50. doi: 10.1179/2049396714Y.0000000102. Epub 2015 Jan 28.

Changes in kidney function among Nicaraguan sugarcane workers.

Abstract

BACKGROUND:

There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers.

OBJECTIVES:

To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria.

METHODS:

We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR).

RESULTS:

eGFR varied by job and decreased during the harvest in seed cutters (-8·6 ml/min/1·73 m(2)), irrigators (-7·4 ml/min/1·73 m(2)), and cane cutters (-5·0 ml/min/1·73 m(2)), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR) >30 mg/g.

CONCLUSIONS:

The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.

KEYWORDS:

Chronic kidney disease of nontraditional etiology,; Chronic kidney disease,; Estimated glomerular filtration rate,; Mesoamerican Nephropathy,; Serum creatinine,; Tubulointerstitial

PMID:
25631575
PMCID:
PMC4597013
DOI:
10.1179/2049396714Y.0000000102
[Indexed for MEDLINE]
Free PMC Article

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