Format

Send to

Choose Destination
J Sex Med. 2015 Apr;12(4):1062-9. doi: 10.1111/jsm.12825. Epub 2015 Jan 29.

Peyronie's disease and autoimmunity—a real-life clinical study and comprehensive review.

Author information

1
Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Abstract

INTRODUCTION:

Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear.

AIM:

We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting.

METHODS:

Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification.

MAIN OUTCOME MEASURES:

Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD.

RESULTS:

PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ(2) = 24.7; P < 0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P < 0.01 and OR: 4.90; P < 0.01, respectively).

CONCLUSIONS:

Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.

KEYWORDS:

Autoimmune Disease; Peyronie's Disease; Psoriasis; Sexual Dysfunction

PMID:
25630575
DOI:
10.1111/jsm.12825
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center