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Biomed Res Int. 2015;2015:183074. doi: 10.1155/2015/183074. Epub 2015 Jan 1.

Gender differences in cerebral regional homogeneity of adult healthy volunteers: a resting-state FMRI study.

Author information

1
Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China ; Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China ; Institute of Computer Application of Chinese Medicine, Anhui Academy of Chinese Medicine, Anhui 230038, China.
2
Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China ; Institute of Computer Application of Chinese Medicine, Anhui Academy of Chinese Medicine, Anhui 230038, China.
3
Graduate School, Anhui University of Chinese Medicine, Anhui 230038, China.
4
Department of Electronic Science and Technology, University of Science & Technology of China, Anhui 230027, China.
5
Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China ; Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China.
6
Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China.
7
Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
8
School of Acupuncture & Osteology, Anhui University of Chinese Medicine, Anhui 230038, China.
9
Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China.
10
CAS Key Laboratory of Brain Function & Disease and School of Life Sciences, University of Science & Technology of China, Anhui 230027, China ; Center of Medical Physics and Technology, Hefei Institutes of Physical Science, CAS, Anhui 230031, China.

Abstract

OBJECTIVE:

We sought to use the regional homogeneity (ReHo) approach as an index in the resting-state functional MRI to investigate the gender differences of spontaneous brain activity within cerebral cortex and resting-state networks (RSNs) in young adult healthy volunteers.

METHODS:

One hundred and twelve healthy volunteers (56 males, 56 females) participated in the resting-state fMRI scan. The ReHo mappings in the cerebral cortex and twelve RSNs of the male and female groups were compared.

RESULTS:

We found statistically significant gender differences in the primary visual network (PVN) (P < 0.004, with Bonferroni correction) and left attention network (LAtN), default mode network (DMN), sensorimotor network (SMN), executive network (EN), and dorsal medial prefrontal network (DMPFC) as well (P < 0.05, uncorrected). The male group showed higher ReHo in the left precuneus, while the female group showed higher ReHo in the right middle cingulate gyrus, fusiform gyrus, left inferior parietal lobule, precentral gyrus, supramarginal gyrus, and postcentral gyrus.

CONCLUSIONS:

Our results suggested that men and women had regional specific differences during the resting-state. The findings may improve our understanding of the gender differences in behavior and cognition from the perspective of resting-state brain function.

PMID:
25629038
PMCID:
PMC4299532
DOI:
10.1155/2015/183074
[Indexed for MEDLINE]
Free PMC Article

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