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Front Microbiol. 2015 Jan 13;5:781. doi: 10.3389/fmicb.2014.00781. eCollection 2014.

Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance.

Author information

1
Department of Medical Nanobiotechnology, Pirogov Russian State Medical University , Moscow, Russia ; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center , Miami Beach, FL, USA ; Research Center for Children's Health , Moscow, Russia.
2
Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales , Sydney, NSW, Australia ; School of Medicine, University of Western Sydney , Campbelltown, NSW, Australia.
3
Department of Oral and Diagnostic Sciences, Columbia University , New York, NY, USA.
4
Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia ; Department of Oral and Diagnostic Sciences, Columbia University , New York, NY, USA ; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex , Moscow, Russia.
5
Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia.

Abstract

The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal tolerance.

KEYWORDS:

harmful antigens; immune system; intestinal microbiota; microflora; tolerance

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