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Stroke. 2015 Mar;46(3):697-703. doi: 10.1161/STROKEAHA.114.008181. Epub 2015 Jan 27.

Isolated MCA disease in patients without significant atherosclerotic risk factors: a high-resolution magnetic resonance imaging study.

Author information

1
From the Department of Neurology (S.-H.A., J.L., Y.-J.K., S.U.K., D.-W.K., J.S.K.) and Neuroradiology (D.L., S.-C.J.), University of Ulsan, Asan Medical Center, Seoul, South Korea.
2
From the Department of Neurology (S.-H.A., J.L., Y.-J.K., S.U.K., D.-W.K., J.S.K.) and Neuroradiology (D.L., S.-C.J.), University of Ulsan, Asan Medical Center, Seoul, South Korea. jongskim@amc.seoul.kr.

Erratum in

Abstract

BACKGROUND AND PURPOSE:

Diagnosis of intracranial artery atherosclerosis remains often uncertain. The high-resolution magnetic resonance imaging (HR-MRI) enables vessel wall assessment for more precise diagnoses. The aim of the present study was to investigate the etiologies of middle cerebral artery steno-occlusive disease in young adult patients with few atherosclerotic risk factors using HR-MRI.

METHODS:

We prospectively studied patients who visited a tertiary hospital in Seoul, Korea, and had (1) unilateral middle cerebral artery disease (≥50% stenosis or occlusion), (2) were ≤55 years old and had no or minimal (≤1) atherosclerotic risk factors. We excluded patients with a confirmed diagnosis of Moyamoya disease, vasculitis, or dissection and those having emboligenic sources. A presumptive diagnosis was made based on HR-MRI findings, and patients were categorized as HR-athero (atherosclerotic disease), HR-MMD (Moyamoya disease), HR-dissection, or HR-vasculitis.

RESULTS:

Among 95 patients analyzed, 26 (27.4%) had HR-athero who were more often male (P=0.004), smokers (P=0.018), and had focal stenosis (P=0.003) than others.As compared with the HR-athero patients, 29 HR-MMD patients were more often female (P<0.001) and more often had occlusive lesions (P=0.001) and nonfocal stenosis (P<0.001). The 22 HR-dissection patients tended to have hypertension less often, and the 13 HR-vasculitis patients were younger (P=0.004) and tended to have nonfocal stenosis. [corrected].

CONCLUSIONS:

In our cohort of young patients with minimal risk factors, atherosclerosis seems to be an uncommon pathology of middle cerebral artery stenosis. HR-MRI aids us to make a more reliable diagnosis.

KEYWORDS:

Moyamoya disease; atherosclerosis; dissection; middle cerebral artery

PMID:
25628303
DOI:
10.1161/STROKEAHA.114.008181
[Indexed for MEDLINE]

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