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J Am Chem Soc. 2015 Feb 11;137(5):1730-3. doi: 10.1021/ja5101307. Epub 2015 Jan 28.

Self-assembly of responsive multilayered DNA nanocages.

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Department of Chemistry and ‡Markey Center for Structural Biology and Department of Biological Sciences, Purdue University , West Lafayette, Indiana 47907, United States.


Here we report the assembly of multilayered DNA nanocages. The layers can be separated in response to a chemical cue, ATP. This is an effort to increase the structural complexity of DNA nanocages. The structures have been characterized by native polyacrylamide gel electrophoresis, atomic force microscopy, and cryogenic electron microscopy. We envision that the layer-by-layer assembly strategy used in this study can be easily applied to other DNA nanocages to form Russian-doll-like semisolid structures, while the chemically activated layer separation makes a contribution to the development of "smart" DNA nanocages.

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