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Sci Rep. 2015 Jan 28;5:8090. doi: 10.1038/srep08090.

SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology.

Author information

1
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

Abstract

Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable of generating a Boolean function play critically important roles in synthetic biology. Basic genetic logic gates have been designed to combine biological science with digital logic. SynBioLGDB (http://bioinformatics.ac.cn/synbiolgdb/) aims to provide the synthetic biology community with a useful resource for efficient browsing and visualization of genetic logic gates. The current version of SynBioLGDB documents more than 189 genetic logic gates with experimental evidence involving 80 AND gates and 16 NOR gates, etc. in three species (Human, Escherichia coli and Bacillus clausii). SynBioLGDB provides a user-friendly interface through which conveniently to query and browse detailed information about these genetic logic gates. SynBioLGDB will enable more comprehensive understanding of the connection of genetic logic gates to execute complex cellular functions in living cells.

PMID:
25627341
PMCID:
PMC4308699
DOI:
10.1038/srep08090
[Indexed for MEDLINE]
Free PMC Article

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