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Ophthalmology. 2015 May;122(5):925-33. doi: 10.1016/j.ophtha.2014.12.018. Epub 2015 Jan 24.

Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study.

Author information

1
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Itoh Clinic, Saitama, Japan; Department of Ophthalmology, University of Tokyo, Tokyo, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Electronic address: ritoh@za2.so-net.ne.jp.
2
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
3
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
4
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, University of Tokyo, Tokyo, Japan.
5
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
6
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.
7
Lid and Meibomian Gland Working Group, Japan; Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Japan.
8
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Abstract

PURPOSE:

To compare tear film parameters as well as meibomian gland morphologic features and function among patients with meibomian gland dysfunction (MGD), those with non-Sjögren syndrome aqueous-deficient dry eye (non-SS ADDE), those with non-SS ADDE and MGD, and normal subjects.

DESIGN:

Multicenter, cross-sectional, observational case series.

PARTICIPANTS:

Forty-one eyes of 41 patients (all women; mean age ± standard deviation, 62.1±9.9 years) with non-SS ADDE, 70 eyes of 70 patients (all women; 66.0±8.7 years) with MGD, 17 eyes of 17 patients (all women; 72.4±7.8 years) with non-SS ADDE and MGD, and 70 eyes of 70 normal control subjects (all women; 65.0±7.1 years).

METHODS:

Ocular symptoms were scored from 0 to 14 and lid margin abnormalities from 0 to 4 according to their respective number. Meibomian gland changes were scored from 0 to 6 (meiboscore) on the basis of noncontact meibography findings, and meibum was graded from 0 to 3 depending on its volume and quality. Conjunctival and corneal epithelial damage were scored from 0 to 9 (fluorescein score). Tear film break-up time (TBUT) was measured as an index of tear film stability, and tear fluid production was evaluated with Schirmer's test.

MAIN OUTCOME MEASURES:

Ocular symptom score, lid margin abnormality score, meiboscore, meibum grade, fluorescein score, TBUT, and Schirmer's test value.

RESULTS:

The ocular symptom score did not differ significantly between the MGD and non-SS ADDE groups (P = 0.762). The lid margin abnormality score, meiboscore, and meibum grade were significantly higher in the MGD group than in the non-SS ADDE group (P = 0.0012, P < 0.0001, and P < 0.0001, respectively). The fluorescein score, TBUT, and Schirmer's test value were significantly worse in the non-SS ADDE group than in the MGD group (P < 0.0001, P = 0.0061, and P < 0.0001, respectively). The meiboscore correlated significantly with Schirmer's test value only in the MGD group (ρ = 0.508, P = 8.3×10(-6)).

CONCLUSIONS:

An increase in tear fluid production likely compensates for loss of meibomian glands in individuals with MGD.

PMID:
25626757
DOI:
10.1016/j.ophtha.2014.12.018
[Indexed for MEDLINE]
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