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BMC Infect Dis. 2015 Jan 23;15:25. doi: 10.1186/s12879-015-0754-x.

Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment.

Author information

1
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. tong.van-hoang@uni-tuebingen.de.
2
Institute of Tropical Medicine, University of Tübingen, Wilhelmstr. 27, 72074, Tübingen, Germany. tong.van-hoang@uni-tuebingen.de.
3
Tran Hung Dao Hospital, 108 Institute of Clinical Medical and Pharmaceutical Sciences, No 1 Tran Hung Dao Street, Hai Ba Trung District, Hanoi, Vietnam. lehuusongdr108@yahoo.com.vn.
4
Tran Hung Dao Hospital, 108 Institute of Clinical Medical and Pharmaceutical Sciences, No 1 Tran Hung Dao Street, Hai Ba Trung District, Hanoi, Vietnam. nghiemxuanhoan@gmail.com.
5
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. buikhaccuong@gmail.com.
6
Department of Pathophysiology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam. buikhaccuong@gmail.com.
7
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. tiensy2015@yahoo.com.
8
Robert Koch Institute, Seestrasse 10, D-13353, Berlin, Germany. tiensy2015@yahoo.com.
9
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. hoanhsonhp@gmail.com.
10
Department of Pathophysiology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam. hoanhsonhp@gmail.com.
11
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. dobaquyet@yahoo.com.
12
Vietnam Military Medical Bureau, No 276 Nghi Tam, Tay Ho District, Hanoi, Vietnam. vq.binh@yahoo.com.vn.
13
Institute of Tropical Medicine, University of Tübingen, Wilhelmstr. 27, 72074, Tübingen, Germany. peter.kremsner@uni-tuebingen.de.
14
Robert Koch Institute, Seestrasse 10, D-13353, Berlin, Germany. BockC@rki.de.
15
Institute of Tropical Medicine, University of Tübingen, Wilhelmstr. 27, 72074, Tübingen, Germany. velavan@medizin.uni-tuebingen.de.
16
Fondation Congolaise pour la Recherche Medicale, P.O Box 2672, Brazzaville, Republic of Congo. velavan@medizin.uni-tuebingen.de.
17
Vietnam Military Medical University, 160 Phung Hung Street, Ha Dong District, Ha Noi, Viet Nam. toannl@vmmu.edu.vn.
18
Department of Pathophysiology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam. toannl@vmmu.edu.vn.

Abstract

BACKGROUND:

The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases including cancer.

METHODS:

The study investigated the prognostic role of soluble MICB (sMICB) protein in the progression of HBV-related liver diseases and to HBV-related HCC treatment. The sMICB serum levels were measured in 266 chronic HBV-infected Vietnamese patients and in healthy controls, and correlated with clinical and laboratory parameters and with therapeutic interventions for HBV-related HCC.

RESULTS:

Significant differences in both clinical and laboratory parameters were observed among the patient groups with different stages of hepatitis. The platelet counts were significantly decreased with disease progression (P < 0.001). The sMICB serum levels were significantly increased in HBV patients compared to healthy controls (P < 0.0001). Among the patients with different stages of hepatitis, asymptomatic individuals (ASYM) revealed higher sMICB serum levels while liver cirrhosis (LC) patients revealed lower sMICB serum levels (P < 0.0001) compared to other patient groups. Notably, the sMICB serum levels were decreased in treated HCC patient group compared to not-treated HCC patient group (P = 0.05). Additionally, the sMICB levels were significantly correlated with platelet counts in ASYM and HCC patients (r = -0.37, P = 0.009; and r = 0.22, P = 0.025, respectively).

CONCLUSIONS:

Our results demonstrate a potential role of sMICB serum levels and platelet counts during immune response to the HBV infection, liver disease progression and response to the HCC treatment.

PMID:
25626490
PMCID:
PMC4318451
DOI:
10.1186/s12879-015-0754-x
[Indexed for MEDLINE]
Free PMC Article

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