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Int J Cancer. 2015 Aug 15;137(4):776-83. doi: 10.1002/ijc.29456. Epub 2015 Feb 13.

Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women.

Author information

1
Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
2
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
3
Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
4
Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
5
Department of Pathology, Harvard Medical School, Boston, MA.
6
Cancer Program, The Broad Institute of MIT and Harvard University, Cambridge, MA.
7
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
8
Harvard Medical School, Pediatric Surgical Laboratories, Massachusetts General Hospital, Boston, MA.
9
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN.
10
Division of Psychiatric Genomics, Mount Sinai School of Medicine, New York, NY.
11
Division of Gynecologic Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada.
12
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
13
Cancer Genomics Informatics and Computational Biology, The Broad Institute of Harvard and MIT, Cambridge, MA.
14
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Abstract

Although the rates of cervical squamous cell carcinoma have been declining, the rates of cervical adenocarcinoma are increasing in some countries. Outcomes for advanced cervical adenocarcinoma remain poor. Precision mapping of genetic alterations in cervical adenocarcinoma may enable better selection of therapies and deliver improved outcomes when combined with new sequencing diagnostics. We present whole-exome sequencing results from 15 cervical adenocarcinomas and paired normal samples from Hong Kong Chinese women. These data revealed a heterogeneous mutation spectrum and identified several frequently altered genes including FAT1, ARID1A, ERBB2 and PIK3CA. Exome sequencing identified human papillomavirus (HPV) sequences in 13 tumors in which the HPV genome might have integrated into and hence disrupted the functions of certain exons, raising the possibility that HPV integration can alter pathways other than p53 and pRb. Together, these provisionary data suggest the potential for individualized therapies for cervical adenocarcinoma based on genomic information.

KEYWORDS:

HPV; cervical adenocarcinoma; genomic alternations

PMID:
25626421
DOI:
10.1002/ijc.29456
[Indexed for MEDLINE]
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