Format

Send to

Choose Destination
Cardiovasc Ultrasound. 2015 Jan 27;13:6. doi: 10.1186/1476-7120-13-6.

Structural and functional changes in maternal left ventricle during pregnancy: a three-dimensional speckle-tracking echocardiography study.

Cong J1,2,3,4, Fan T5, Yang X6,7,8, Squires JW9, Cheng G10,11,12, Zhang L13,14, Zhang Z15,16,17.

Author information

1
Department of Ultrasonic Diagnosis, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. congjuan0725@163.com.
2
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. congjuan0725@163.com.
3
Henan Provincial Engineering Research Center for Perinatal Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. congjuan0725@163.com.
4
Henan Translational Medicine Engineering Laboratory for Maternal and Children's Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. congjuan0725@163.com.
5
Department of Ultrasonic Diagnosis, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. fan_tingpan@126.com.
6
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. yangxiaoqian1986@163.com.
7
Henan Provincial Engineering Research Center for Perinatal Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. yangxiaoqian1986@163.com.
8
Henan Translational Medicine Engineering Laboratory for Maternal and Children's Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. yangxiaoqian1986@163.com.
9
Department of Surgical Oncology, Massachusetts General Hospital, Boston, 02114, MA, USA. jwsquires@partners.org.
10
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. 13803810939@126.com.
11
Henan Provincial Engineering Research Center for Perinatal Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. 13803810939@126.com.
12
Henan Translational Medicine Engineering Laboratory for Maternal and Children's Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. 13803810939@126.com.
13
Henan Provincial Engineering Research Center for Perinatal Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. linlinzlynn@163.com.
14
Henan Translational Medicine Engineering Laboratory for Maternal and Children's Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. linlinzlynn@163.com.
15
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. zhangzhanzdsfy@126.com.
16
Henan Provincial Engineering Research Center for Perinatal Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. zhangzhanzdsfy@126.com.
17
Henan Translational Medicine Engineering Laboratory for Maternal and Children's Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. zhangzhanzdsfy@126.com.

Abstract

BACKGROUND:

Pregnancy represents a physiological adaptation to the transient load changes of maternal heart. This study aimed to investigate maternal left ventricle (LV) performance during normal pregnancy by three-dimensional speckle-tracking echocardiography (3D STE) parameters considering LV loading and shape.

METHODS:

Sequential two-dimensional echocardiography (2DE) and 3D STE were performed on 68 women during each pregnancy trimester and 6 to 9 weeks after delivery, while thirty age-matched, healthy, nonpregnant women served as controls. Global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS) and global radial strain (GRS) were measured.

RESULTS:

Increased cardiac index and progressive eccentric hypertrophy was detected, which subsequently recovered postpartum. In late pregnancy, GLS, GCS, GAS and GRS significantly decreased (P < 0.05) accompanied by a slight reduction of LV ejection fraction (EF) (P < 0.05), and these values returned postpartum to baseline level. All 3D strain indices correlated well with gestation age (P < 0.01), while compared to other components, GAS exhibited the strongest association with 3D EF (r = 0.549) and sphericity index (r = 0.328), and was the only parameter that correlated well with LV mass index (r = 0.22).

CONCLUSIONS:

This study gives normal ranges of 3D STE indices in pregnancy. 3D STE demonstrated modified myocardial deformation and changes in maternal LV structure and function during the gestation period.

PMID:
25626356
PMCID:
PMC4417318
DOI:
10.1186/1476-7120-13-6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center