Format

Send to

Choose Destination
See comment in PubMed Commons below
BJOG. 2016 Feb;123(3):400-7. doi: 10.1111/1471-0528.13274. Epub 2015 Jan 27.

Prenatal detection of congenital heart disease--results of a national screening programme.

Author information

1
Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, the Netherlands.
2
Department of Pediatric Cardiology, Academic Medical Centre, Emma Children's Hospital, Amsterdam, the Netherlands.
3
Department of Paediatric Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.
4
Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands.
5
Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands.
6
Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
7
Department of Paediatric Cardiology, VU University Medical Centre, Amsterdam, the Netherlands.
8
Department of Obstetrics and Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands.

Abstract

OBJECTIVE:

Congenital heart disease (CHD) is the most common congenital malformation and causes major morbidity and mortality. Prenatal detection improves the neonatal condition before surgery, resulting in less morbidity and mortality. In the Netherlands a national prenatal screening programme was introduced in 2007. This study evaluates the effects of this screening programme.

DESIGN:

Geographical cohort study.

SETTING:

Large referral region of three tertiary care centres.

POPULATION:

Fetuses and infants diagnosed with severe CHD born between 1 January 2002 and 1 January 2012.

METHODS:

Cases were divided into two groups: before and after the introduction of screening.

MAIN OUTCOME MEASURES:

Detection rates were calculated.

RESULTS:

The prenatal detection rate (n = 1912) increased with 23.9% (95% confidence interval [95% CI] 19.5-28.3) from 35.8 to 59.7% after the introduction of screening and of isolated CHD with 21.4% (95% CI 16.0-26.8) from 22.8 to 44.2%. The highest detection rates were found in the hypoplastic left heart syndrome, other univentricular defects and complex defects with atrial isomerism (>93%). Since the introduction of screening, the 'late' referrals (after 24 weeks of gestation) decreased by 24.3% (95% CI 19.3-29.3).

CONCLUSIONS:

This is the largest cohort study to investigate the prenatal detection rate of severe CHD in an unselected population. A nationally organised screening has resulted in a remarkably high detection rate of CHD (59.7%) compared with earlier literature.

KEYWORDS:

Congenital heart defects; detection rate; fetal echocardiography; prenatal anomaly screening; prenatal diagnosis

PMID:
25625301
DOI:
10.1111/1471-0528.13274
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center