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Biochem Biophys Res Commun. 2015 Feb 27;458(1):63-9. doi: 10.1016/j.bbrc.2015.01.066. Epub 2015 Jan 24.

miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7.

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Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address:
Department of Radiation Oncology, Yueyang Second People's Hospital, Yueyang 414000, China.


MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3'-untranslated region (3'UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer.


Cervical cancer; FBXW7; Invasion; Proliferation; miR-92a

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